Surgery Godfather

Chapter 2259: Chapter 1466: Major Breakthrough (2)

Yang Ping quickly skimmed through it. The little girl’s learning ability was astonishing; she corrected all the issues pointed out last time, and the quality of the newly added content was very high. She not only read those three papers but also made a summary table of several key data points and placed it at the end as an appendix.

He replied with a brief email: "Significant progress, good literature reading skills, but data interpretation still needs improvement."

After sending it, he glanced again at the summary table; the data was accurate. For a fifteen-year-old, achieving this level was already remarkable. But he wouldn’t say "already remarkable," because saying so wouldn’t benefit her. She’s still young and needs standards, not consolation.

The routine meeting started promptly at two in the afternoon.

The meeting room was full, and the atmosphere was noticeably different from last week. Back then, everyone was scrambling to solve the issues of temperature exposure duration and CO₂ concentration, but today, there was an uncontainable excitement on everyone’s faces, like a group of miners who had found the gold vein but hadn’t yet struck the gold.

Tang Shun was the first to stand up and walked to the screen.

"Today’s meeting has only one topic: the hypothesis proposed by Professor Yang yesterday, which we’ll tentatively call the ’Embryonic and Repair Unified Hypothesis.’ Manstein, Weber, and I conducted some preliminary verification, and we’ll now report the results."

He pressed a remote control, and a pathway diagram appeared on the screen.

Yang Ping’s breath paused when he saw the diagram. He knew Manstein was drawing it but didn’t expect it to be so well done. The diagram had dozens of proteins and genes arranged densely, connected by differently colored lines, forming a complex network. The center of the network was the unknown factor, radiating outward into three main lines leading to three different functional modules: migration module, proliferation module, differentiation module.

"This is the repair program signal network diagram drawn by Manstein based on mass spectrometry data and bioinformatics analysis," Tang Shun pointed to different areas of the diagram, "Red represents the execution module, commanding Stem Cells proliferation and differentiation; blue represents the communication module, transmitting damage signals and initiating commands; green represents the navigation module, providing pathway guidance for cell migration. The three modules work collaboratively to complete the tissue repair."

A low murmur of discussion rose in the meeting room.

Manstein raised his hand to add: "This network is not static. We analyzed samples from different time points after injury and found that the network’s activation is phased. The first phase is the communication module initiation, roughly completed within minutes to hours after injury; the second phase is the activation of the navigation module, lasting hours to days; the third phase is the execution module entering the scene, lasting days to weeks. The entire process is like a carefully orchestrated symphony, with every instrument sounding when it should and stopping when it should."

Yang Ping looked at the diagram, the dense lines and nodes, and suddenly recalled a word: harmony.

Not deliberate harmony, not harmony designed by human hands, but spontaneous, intrinsic harmony honed through millions of years of evolution. The human body doesn’t need orders; it knows what to do on its own. Doctors’ roles are not to give orders but to remove obstacles so this program can run smoothly.

Tang Shun switched to the next slide, "Weber’s homogenate experiment showed preliminary results that injury tissue homogenates can activate the entire network, not just upregulate the unknown factor. We used single-cell sequencing technology to analyze treated Stem Cells and found changes in the expression of over two hundred genes, which appropriately belong to those three functional modules."

A heat map appeared on the screen, with red representing gene expression upregulation and green representing downregulation. More than two hundred genes formed three clear color blocks on the map, like festive lights.

Tang Shun’s voice carried a touch of admiration.

The meeting room fell silent for a moment; Weber’s chair was empty, with a White Gown draped over the back.

Yang Ping looked at the empty chair, "Tang Shun, go visit Weber’s house this afternoon, bring some fruit, tell him the experiment data looks good and that he can rest easy, come back tomorrow."

"Sure!"

Next was Manstein’s report. He detailed the three proteins highly related to the unknown factor, explaining clearly each one’s structure, function, and interaction relationships. His PPT was as beautifully made as always, with pathway diagrams, scatter plots, bar charts, and heat maps, each meticulously designed, with harmonious colors and clear labeling.

Manstein concluded, "So, we now have a clear hypothesis: after injury, the damaged tissue releases start signals to activate the communication module; the communication module delivers instructions through unknown factors and other signal molecules to the navigation module and execution module; the navigation module provides path guidance, indicating where Stem Cells should appear; the execution module directs Stem Cells to proliferate and differentiate, completing tissue repair. The three modules are indispensable; if any one of them fails, repair will fail."

He paused and glanced around at everyone in the meeting room.

"If this hypothesis is validated, it will fundamentally change our understanding of tissue repair. In the past, we thought repair relied on some miraculous molecule or cell, but now it seems repair is a systemic, multi-module, highly coordinated process. We can’t just focus on one target; we need to consider the entire network."

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